Determination of the relative potency of selected weak endocrine disrupters
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Determination of the relative potency of selected weak endocrine disrupters by Rosalind E. Aitcheson

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Published .
Written in English


Book details:

Edition Notes

Thesis (M.Sc.) - University of Surrey, 1996.

StatementRosalind E. Aitcheson.
ContributionsUniversity of Surrey. School of Biological Sciences.
ID Numbers
Open LibraryOL19356276M

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Two reports, entitled "Research Needs for the Assessment of Health and Environmental Effects of Endocrine Disrupters: A Report of the U.S. EPA-Sponsored Workshop" (Kavlock et al., ) and "Development of a Research Strategy for Assessing the Ecological Risk of Endocrine Disrupters" (Ankley et al., ), have resulted from these meetings. Relative binding affinity (A) is shown as the molar concentration needed to displace 50% 3 H-estradiol from ER in a competitive binding assay. Relative efficacy (B) is shown as the molar concentration needed to stimulate proliferation of MCF7 human breast cancer cells after 14 days. Source: Data taken for (A) from Ref. and (B) from by: 3.   In , the two programmes launched a joint call focused on endocrine disrupters, culminating in the formation of the laboratory, 4-project CREDO (the Cluster of Research into Endocrine Disruption in Europe) cluster, which was formally launched in March (3). 6 other research projects, launched in and (2, 3) are associated to. Endocrine disrupters in wastewater and sludge treatment processes J W Birkett, J N Lester. Year: Publisher: Lewis Pub Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for.

NCEA-C ERASC June NON-DIOXIN-LIKE PCBs: EFFECTS AND CONSIDERATION IN ECOLOGICAL RISK ASSESSMENT by Tala R. Henry and Michael J. DeVito United States Environmental Protection Agency Experimental Toxicology Division National Health and Environmental Effects Research Laboratory Office of Research and Development Ecological Risk Assessment . In vitro reporter gene assay revealed that relative potency of NP to estradiolβ for medaka estrogen receptor α is % [7]. In in vivo experiments, nonylphenol was found to induce vitellogenins (female egg yolk proteins) in the male liver at μg/l in rainbow trout, and at μg/l in medaka [8,9]. A potency balance calcn. based on the instrumental analyses and relative potencies (REPs) of the individual glucocorticoids supports the conclusion that triamcinolone acetonide (REP =), dexamethasone (REP =1), and prednisolone (REP =) are the main contributors to the glucocorticogenic activity in the investigated wastewater by: 3.   Background. Breast cancer (BC) is the most common cancer for women in the western world and the incidence has been increasing since The highest incidence rates are observed in North America, and the lowest risk is found in Asia and Africa [].Breast cancer is also the most common cancer in females in Europe with the highest incidence in The Netherlands and Denmark and lowest .

  For simplicity, to address the question of whether or not endocrine disruptors have the potential to affect reproductive physiology and behavior at low doses, this review will focus on three compounds currently gaining wide scientific and public attention: genistein, bisphenol-a (BPA) and the phthalates. genistein and BPA are classified as weak Cited by:   The EPA formed the Endocrine Disrupters Screening and Testing Advisory Committee (EDSTAC) to devise a rational process for assessing the hazards of environmental endocrine disrupters. While much of the research to date has focused on estrogen disrupters, EDSTAC has chosen to include androgens (so-called “male” hormones) and thyroid hormones. 2. Incidence and Prevalence of Health Problems associated with Endocrine Disruption Have Increased. Epidemiological data show increases in incidence and prevalence of diseases associated with endocrine-disrupting chemicals, such as breast, prostate, and testis cancer, diabetes, obesity, and decreased fertility over the last 50 years. Safe S () Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach., Environmental Health Perspectives, suppl Cited by: